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DOCUMENT AND ENTITY INFORMATION - shares	6 Months Ended
DOCUMENT AND ENTITY INFORMATION - shares	Jun. 30, 2019	Aug. 07, 2019
Document and Entity Information
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2019
Entity Registrant Name	YIELD10 BIOSCIENCE, INC.
Entity Central Index Key	0001121702
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q2
Entity Current Reporting Status	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		12,519,017

CONDENSED CONSOLIDATED BALANCE SHEETS UNAUDITED - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Current Assets:
Cash and cash equivalents	$ 3,252	$ 3,023
Short-term investments	998	2,746
Accounts receivable	148	94
Unbilled receivables	103	66
Prepaid expenses and other current assets	516	448
Total current assets	5,017	6,377
Restricted cash	332	332
Property and equipment, net	1,298	1,385
Right-of-use assets	4,467	4,766
Other assets	42	100
Total assets	11,156	12,960
Current Liabilities:
Accounts payable	55	117
Accrued expenses	586	680
Lease liabilities	865	844
Total current liabilities	1,506	1,641
Lease liabilities, net of current portion	5,196	5,621
Total liabilities	6,702	7,262
Commitments and contingencies (Note 9)
Stockholders’ Equity:
Preferred Stock ($0.01 par value per share); 5,000,000 shares authorized; no shares issued or outstanding	0	0
Common stock ($0.01 par value per share); 60,000,000 shares authorized at June 30, 2019 and December 31, 2018; 12,494,731 and 10,025,811 shares issued and outstanding at June 30, 2019 and December 31, 2018, respectively	125	100
Additional paid-in capital	360,516	357,646
Accumulated other comprehensive loss	(118)	(110)
Accumulated deficit	(356,069)	(351,938)
Total stockholders’ equity	4,454	5,698
Total liabilities and stockholders’ equity	$ 11,156	$ 12,960

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS UNAUDITED - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenue:
Revenue	$ 318	$ 285	$ 442	$ 345
Expenses:
Research and development	1,191	1,260	2,414	2,361
General and administrative	1,025	1,456	2,211	2,732
Total expenses	2,216	2,716	4,625	5,093
Loss from operations	(1,898)	(2,431)	(4,183)	(4,748)
Other income (expense), net	27	38	52	63
Net loss	$ (1,871)	$ (2,393)	$ (4,131)	$ (4,685)
Basic and diluted net loss per share (in USD per share)	$ (0.15)	$ (0.24)	$ (0.36)	$ (0.48)
Number of shares used in per share calculations:
Basic and diluted (in shares)	12,494,337	9,991,460	11,504,314	9,845,902
Grant
Revenue:
Revenue	$ 318	$ 285	$ 442	$ 345

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Jun. 30, 2019	Dec. 31, 2018
Statement of Financial Position [Abstract]
Preferred stock, par value per share (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, authorized (in shares)	5,000,000	5,000,000
Preferred stock, issued (in shares)	0	0
Preferred stock, outstanding (in shares)	0	0
Common stock, par value per share (in dollars per share)	$ 0.01	$ 0.01
Common stock, authorized (in shares)	60,000,000	60,000,000
Common stock, issued (in shares)	12,494,731	10,025,811
Common stock, outstanding (in shares)	12,494,731	10,025,811

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS UNAUDITED - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Statement of Comprehensive Income [Abstract]
Net loss:	$ (1,871)	$ (2,393)	$ (4,131)	$ (4,685)
Other comprehensive loss
Change in unrealized gain (loss) on investments	0	(1)	0	0
Change in foreign currency translation adjustment	(3)	(9)	(8)	(14)
Total other comprehensive loss	(3)	(10)	(8)	(14)
Comprehensive loss	$ (1,874)	$ (2,403)	$ (4,139)	$ (4,699)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS UNAUDITED - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Statement of Cash Flows [Abstract]
Excess Tax Benefit from Share-based Compensation, Financing Activities	$ (4)	$ (6)
Cash flows from operating activities
Net loss	(4,131)	(4,685)
Adjustments to reconcile net loss to cash used in operating activities:
Depreciation	100	96
Charge for 401(k) company common stock match	49	70
Stock-based compensation	275	596
Non-cash lease expense	299	145
Changes in operating assets and liabilities:
Accounts receivables	(54)	54
Unbilled receivables	(37)	22
Prepaid expenses and other assets	(10)	(56)
Accounts payable	(62)	(42)
Accrued expenses	(102)	(926)
Lease liabilities	(404)	(162)
Net cash used for operating activities	(4,077)	(4,888)
Cash flows from investing activities
Purchase of property and equipment	(13)	(34)
Purchase of short-term investments	(998)	(7,986)
Proceeds from the sale and maturity of short-term investments	2,746	1,500
Net cash provided by (used for) investing activities	1,735	(6,520)
Cash flows from financing activities
Proceeds from warrants exercised	0	124
Proceeds from registered direct offering, net of issuance costs	2,583	0
Net cash provided by financing activities	2,579	118
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(8)	(14)
Net increase (decrease) in cash, cash equivalents and restricted cash	229	(11,304)
Cash, cash equivalents and restricted cash at beginning of period	3,355	14,804
Cash, cash equivalents and restricted cash at end of period	3,584	3,500
Supplemental disclosure of non-cash information:
Right-of-use assets acquired in exchange for lease liabilities	$ 0	$ 74

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Series B Warrant	Preferred Stock	Common Stock	Common Stock Series B Warrant	Additional Paid-In Capital	Additional Paid-In Capital Series B Warrant	Accumulated other Comprehensive Loss	Accumulated Deficit
Balance (in shares) at Dec. 31, 2017			1,826	9,089,159
Balance at Dec. 31, 2017	$ 13,502		$ 818	$ 91		$ 355,431		$ (85)	$ (342,753)
Increase (decrease) in stockholders' equity
Non-cash stock-based compensation expense	596					596
Issuance of common stock for 401k match (in shares)				31,760
Issuance of common stock for 401k match	59					59
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes (in shares)				4,401
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes	(6)					(6)
Issuance of common stock for registered direct offering and conversion of warrants (in shares)					55,100
Issuance of common stock for registered direct offering and conversion of warrants		$ 124			$ 1		$ 123
Issuance of common stock upon conversion of Series A Convertible Preferred Stock (in shares)			(1,826)	811,557
Issuance of common stock upon conversion of Series A Convertible Preferred Stock			$ (818)	$ 8		810
Effect of foreign currency translation and unrealized gain on investments	(14)							(14)
Net loss	(4,685)								(4,685)
Balance at Jun. 30, 2018	9,576		$ 0	$ 100		357,013		(99)	(347,438)
Balance (in shares) at Jun. 30, 2018			0	9,991,977
Balance (in shares) at Mar. 31, 2018			0	9,968,455
Balance at Mar. 31, 2018	11,633		$ 0	$ 100		356,667		(89)	(345,045)
Increase (decrease) in stockholders' equity
Non-cash stock-based compensation expense	315					315
Issuance of common stock for 401k match (in shares)				19,121
Issuance of common stock for 401k match	37					37
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes (in shares)				4,401
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes	(6)					(6)
Effect of foreign currency translation and unrealized gain on investments	(10)							(10)
Net loss	(2,393)								(2,393)
Balance at Jun. 30, 2018	$ 9,576		$ 0	$ 100		357,013		(99)	(347,438)
Balance (in shares) at Jun. 30, 2018			0	9,991,977
Balance (in shares) at Dec. 31, 2018	10,025,811		0	10,025,811
Balance at Dec. 31, 2018	$ 5,698		$ 0	$ 100		357,646		(110)	(351,938)
Increase (decrease) in stockholders' equity
Non-cash stock-based compensation expense	275					275
Issuance of common stock for 401k match (in shares)				42,606
Issuance of common stock for 401k match	41					41
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes (in shares)				4,652
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes	(4)					(4)
Issuance of common stock for registered direct offering and conversion of warrants (in shares)				2,421,662
Issuance of common stock for registered direct offering and conversion of warrants	2,583			$ 25		2,558
Effect of foreign currency translation and unrealized gain on investments	(8)							(8)
Net loss	(4,131)								(4,131)
Balance at Jun. 30, 2019	$ 4,454		$ 0	$ 125		360,516		(118)	(356,069)
Balance (in shares) at Jun. 30, 2019	12,494,731		0	12,494,731
Balance (in shares) at Mar. 31, 2019			0	12,468,219
Balance at Mar. 31, 2019	$ 6,195		$ 0	$ 125		360,383		(115)	(354,198)
Increase (decrease) in stockholders' equity
Non-cash stock-based compensation expense	113					113
Issuance of common stock for 401k match (in shares)				21,860
Issuance of common stock for 401k match	24					24
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes (in shares)				4,652
Issuance of stock for restricted stock unit vesting, net of shares withheld for employee taxes	(4)					(4)
Effect of foreign currency translation and unrealized gain on investments	(3)							(3)
Net loss	(1,871)								(1,871)
Balance at Jun. 30, 2019	$ 4,454		$ 0	$ 125		$ 360,516		$ (118)	$ (356,069)
Balance (in shares) at Jun. 30, 2019	12,494,731		0	12,494,731

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Statement of Stockholders' Equity [Abstract]
Shares withheld for employee taxes	2,449	2,703	2,449	2,703
Offering costs			$ 349

NATURE OF BUSINESS AND BASIS OF PRESENTATION	6 Months Ended
NATURE OF BUSINESS AND BASIS OF PRESENTATION	Jun. 30, 2019
Organization, Consolidation and Presentation of Financial Statements [Abstract]
NATURE OF BUSINESS AND BASIS OF PRESENTATION	NATURE OF BUSINESS AND BASIS OF PRESENTATION Yield10 Bioscience, Inc. is an agricultural bioscience company which uses its "Trait Factory" to develop high value seed traits for the agriculture and food industries. Specifically, Yield10 plans to efficiently develop superior gene traits for the major grain crops corn, soybean, canola, wheat and rice that will enable step-change increases in crop yield of at least 10-20 percent. While maintaining its focus on the development of novel yield traits for key crops based on a licensing model, the Company has recently begun to execute the second part of its strategy which is to develop independent business opportunities for Yield10 in the specialty oils and niche crop space using the oilseed Camelina. The target of this effort is sustainable business solutions to support agriculture, global food production and other specialty applications. Yield10 brings a unique history, skill set, and tools captured in its Gene Ranking Artificial Intelligence Network ("GRAIN") platform for developing advanced crop traits and increasing the concentration of specific biochemicals of commercial interest in crops. The Company's plan is to develop a source of revenue from funded research and development collaborations for traits, products and crops not being directly pursued internally. While there is no guarantee of success, the Company is currently engaged in a range of discussions with third parties on different crops, traits and products in the feed, food and pharmaceutical sectors. Yield10 Bioscience is headquartered in Woburn, Massachusetts and has an oilseed development Center of Excellence in Saskatoon, Saskatchewan, Canada. The accompanying unaudited condensed consolidated financial statements are unaudited and have been prepared by Yield10 in accordance with accounting principles generally accepted in the United States of America ("GAAP") and pursuant to the rules and regulations of the U.S. Securities and Exchange Commission ("SEC"). Certain information and footnote disclosures normally included in the Company’s annual consolidated financial statements have been condensed or omitted. The year-end condensed consolidated balance sheet data was derived from audited financial statements but does not include all disclosures required by GAAP. The condensed consolidated financial statements, in the opinion of management, reflect all adjustments (consisting only of normal recurring adjustments) necessary for fair statements of the financial position and results of operations for the interim periods ended June 30, 2019 and June 30, 2018. The Company adopted Accounting Standards Update ("ASU") No. 2016-02, Leases, ("Topic 842") on January 1, 2019 using a modified retrospective approach. As a result, the Company's unaudited condensed consolidated balance sheet at December 31, 2018 and its unaudited condensed consolidated statements of operations, comprehensive loss, cash flows and stockholders' equity for the three and six months ended June 30, 2018, included herein, have been adjusted to incorporate the guidance of Topic 842. See Note 8. The results of operations for the interim periods are not necessarily indicative of the results of operations to be expected for any future period or the entire fiscal year. These interim unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2018, which are contained in the Company’s Annual Report on Form 10-K filed with the SEC on March 28, 2019. The accompanying condensed consolidated financial statements have been prepared on a basis which assumes that the Company will continue as a going concern and which contemplates the realization of assets and satisfaction of liabilities and commitments in the normal course of business. With the exception of a single year, the Company has recorded losses since its initial founding, including the three and six months ended June 30, 2019. As of June 30, 2019, the Company held unrestricted cash, cash equivalents and short-term investments of $4,250. The Company follows the guidance of Accounting Standards Codification ("ASC") Topic 205-40, Presentation of Financial Statements-Going Concern, in order to determine whether there is substantial doubt about its ability to continue as a going concern for one year after the date its financial statements are issued. Based on its current cash forecast, management expects that the Company's present capital resources will be sufficient to fund its planned operations and meet its obligations into the fourth quarter of 2019. This forecast of cash resources is forward-looking information that involves risks and uncertainties, and the actual amount of expenses could vary materially and adversely as a result of a number of factors. The Company's ability to continue operations after its current cash resources are exhausted depends on its ability to obtain additional financing through, among other sources, public or private equity financing, secured or unsecured debt financing, equity or debt bridge financing, warrant holders' ability and willingness to exercise the Company's outstanding warrants, additional government grants or collaborative arrangements with third parties, as to which no assurance can be given. Management does not know whether additional financing will be available on terms favorable or acceptable to the Company when needed, if at all. If adequate additional funds are not available when required, management will be forced to curtail the Company's research efforts, explore strategic alternatives and/or wind down its operations and pursue options for liquidating its remaining assets, including intellectual property. Based on its cash forecast, management has determined that the Company's present capital resources will not be sufficient to fund its planned operations for the twelve months from the date that these financial statements are filed, which raises substantial doubt about the Company's ability to continue as a going concern. If the Company issues equity or debt securities to raise additional funds, (i) the Company may incur fees associated with such issuance, (ii) its existing stockholders may experience dilution from the issuance of new equity securities, (iii) the Company may incur ongoing interest expense and be required to grant a security interest in Company assets in connection with any debt issuance, and (iv) the new equity or debt securities may have rights, preferences and privileges senior to those of the Company’s existing stockholders. In addition, utilization of the Company’s net operating loss and research and development credit carryforwards may be subject to significant annual limitations under Section 382 of the Internal Revenue Code of 1986, as amended, due to ownership changes resulting from equity financing transactions. If the Company raises additional funds through collaboration, licensing or other similar arrangements, it may be necessary to relinquish valuable rights to its potential products or proprietary technologies or grant licenses on terms that are not favorable to the Company.

ACCOUNTING POLICIES

6 Months Ended

Jun. 30, 2019

Accounting Policies [Abstract]

ACCOUNTING POLICIES

From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board ("FASB") or other standard setting bodies that the Company adopts as of the specified effective date. During the six months ended June 30, 2019, the Company adopted the following new accounting guidance.

In February 2016, the FASB issued ASU No. 2016-02, which requires lessees to recognize most leases on their balance sheet as right-of-use assets and lease liabilities. In July 2018, the FASB issued ASU No. 2018-10, "Codification Improvements to Topic 842, Leases" ("ASU 2018-10"), which provided narrow amendments to clarify how to apply certain aspects of the new lease standard, and ASU No. 2018-11, "Leases (Topic 842 - Targeted Improvements)" ("ASU 2018-11"), which addressed implementation issues related to the new lease standard. The new guidance was effective for annual reporting periods beginning after December 15, 2018 and interim periods within those fiscal years. Under the new standard, disclosures are required to enable users of financial statements to better assess the amount, timing, and uncertainty of cash flows arising from leases. Topic 842 required filers to adopt the new standard using a modified retrospective approach under either of two transition methods; (1) to apply the new lease requirements at the beginning of the earliest period presented, or (2) to apply the new lease requirements at the effective date. The Company adopted the new standard on January 1, 2019 and elected to adjust its 2018 financial statements in order to make them comparable to its 2019 financial statements. Adoption of Topic 842 had a material impact on the Company's previously reported 2018 financial statements. See Note 8.

New pronouncements that are not yet effective but may impact the Company's financial statements in the future are described below.

In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments. The FASB has subsequently issued amendments to ASU 2016-13, which have the same effective date and transition date of January 1, 2020. These standards require that credit losses be reported using an expected losses model rather than the incurred losses model that is currently used, and establishes additional disclosures related to credit risks. For available-for-sale debt securities with unrealized losses, this standard now requires allowances to be recorded instead of reducing the amortized cost of the investment. These standards limit the amount of credit losses to be recognized for available-for-sale debt securities to the amount by which carrying value exceeds fair value and requires the reversal of previously recognized credit losses if fair value increases. The Company is still evaluating the potential impact of the standard on its consolidated financial position, results of operations and related disclosures.

In August 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework - Changes to the Disclosure Requirements for Fair Value Measurement. This standard modifies certain disclosure requirements on fair value measurements and will become effective for the Company on January 1, 2020. The Company is still evaluating the potential impact of the standard on its consolidated financial position and results of operations and related disclosures.

In November 2018, the FASB issued ASU No. 2018-18, Collaborative Arrangements (Topic 808): Clarifying the Interaction between Topic 808 and Topic 606. This standard makes targeted improvements for collaborative arrangements as follows:

•

Clarifies that certain transactions between collaborative arrangement participants should be accounted for as revenue under ASC 606, Revenue from Contracts with Customers, when the collaborative arrangement participant is a customer in the context of a unit of account. In those situations, the guidance in ASC 606 should be applied, including recognition, measurement, presentation and disclosure requirements;


•	Adds unit-of-account guidance to ASC 808, Collaborative Arrangements, to align with the guidance in ASC 606 (that is, a distinct good or service) when an entity is assessing whether the collaborative arrangement or a part of the arrangement is within the scope of ASC 606; and


•	Precludes a company from presenting transactions with collaborative arrangement participants that are not directly related to sales to third parties with revenue recognized under ASC 606 if the collaborative arrangement participant is not a customer.

This standard will become effective for the Company on January 1, 2020; however, early adoption is permitted. A retrospective transition approach is required for either all contracts or only for contracts that are not completed at the date of initial application of ASC 606, with a cumulative adjustment to opening retained earnings, as of January 1, 2019. The Company is currently evaluating the potential impact that this standard may have on its consolidated financial position, results of operations and related disclosures.

Principles of Consolidation

The Company's unaudited condensed consolidated financial statements are prepared in accordance with accounting principles generally accepted in the United States of America. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany transactions were eliminated, including transactions with its Canadian subsidiary, Metabolix Oilseeds, Inc.

Cash, Cash Equivalents and Restricted Cash

The Company considers all highly liquid investments purchased with an original maturity date of ninety days or less at the date of purchase to be cash equivalents.

The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the Company's Unaudited Condensed Consolidated Balance Sheets included herein:



	June 30, 2019		December 31, 2018
Cash and cash equivalents	$	3,252	$	3,023
Restricted cash	332		332
Total cash, cash equivalents and restricted cash	$	3,584	$	3,355

Amounts included in restricted cash represent those required to be set aside by contractual agreement. Restricted cash of $332 at June 30, 2019 and December 31, 2018 consists of funds held in connection with the Company's lease agreement for its Woburn, Massachusetts facility.

Investments

The Company considers all investments purchased with an original maturity date of more than ninety days at the date of purchase and a maturity date of one year or less at the balance sheet date to be short-term investments. All other investments are classified as long-term. The Company held no long-term investments at June 30, 2019 and December 31, 2018.

Other-than-temporary impairments of equity investments are recognized in the Company's statements of operations if the Company has experienced a credit loss and has the intent to sell the investment or if it is more likely than not that the Company will be required to sell the investment before recovery of the amortized cost basis. Realized gains and losses, dividends, interest income and declines in value judged to be other-than-temporary credit losses are included in other income (expense). Any premium or discount arising at purchase is amortized and/or accreted to interest income.

Use of Estimates

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of grant revenue and expenses during the reporting periods. Actual results could differ from those estimates.

Foreign Currency Translation

Foreign denominated assets and liabilities of the Company's wholly owned foreign subsidiaries are translated into U.S. dollars at the prevailing exchange rates in effect on the balance sheet date. Revenues and expenses are translated at average exchange rates prevailing during the period. Any resulting translation gains or losses are recorded in accumulated other comprehensive income (loss) in the consolidated balance sheet. When the Company dissolves, sells or substantially sells all of the assets of a consolidated foreign subsidiary, the cumulative translation gain or loss of that subsidiary is released from comprehensive income (loss) and included within its consolidated statement of operations during the fiscal period when the dissolution or sale occurs.

Income Taxes

The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the consolidated financial statements or in the Company's tax returns. Under this method, deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. A valuation allowance is provided to reduce the deferred tax asset to a level which, more likely than not, will be realized.

Concentration of Credit Risk

Financial instruments that potentially subject the Company to concentrations of credit risk primarily consist of cash, cash equivalents and investments. The Company has historically invested its cash equivalents in highly rated money market funds, corporate debt, federal agency notes and U.S. treasury notes. Investments, when purchased, are acquired in accordance with the Company’s investment policy which establishes a concentration limit per issuer.

At June 30, 2019, 100% of the Company's total accounts and unbilled receivables of $251 are due from U.S. government grants.

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE

6 Months Ended

Jun. 30, 2019

Earnings Per Share [Abstract]

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE

Basic net income (loss) per share is computed by dividing net income (loss) by the weighted-average number of common shares outstanding. Diluted net income (loss) per share is computed by dividing net income (loss) by the weighted-average number of dilutive common shares outstanding during the period. Diluted shares outstanding is calculated by adding to the weighted shares outstanding any potential (unissued) shares of common stock from outstanding stock options and warrants based on the treasury stock method, as well as weighted shares outstanding of any potential (unissued) shares of common stock from restricted stock units. In periods when a net loss is reported, all common stock equivalents are excluded from the calculation because they would have an anti-dilutive effect, meaning the loss per share would be reduced. Therefore, in periods when a loss is reported, basic and dilutive loss per share are the same. Common stock equivalents include stock options, restricted stock awards and warrants.

The number of shares of potentially dilutive common stock presented on a weighted average basis, related to options, restricted stock units and warrants (prior to consideration of the treasury stock method) that were excluded from the calculation of dilutive shares since the inclusion of such shares would be anti-dilutive for the three and six months ended June 30, 2019 and June 30, 2018, respectively, are shown below. Issued and outstanding warrants shown in the table below are described in greater detail in Note 11, contained herein.



	Three Months Ended June 30,		Six Months Ended June 30,
	2019	2018	2019	2018
Options	2,027,870	1,117,827	1,874,968	910,427
Restricted stock units	—	7,101	3,531	10,660
Warrants	7,368,254	10,597,486	7,400,490	10,597,486
Total	9,396,124	11,722,414	9,278,989	11,518,573

INVESTMENTS

6 Months Ended

Jun. 30, 2019

Investments, Debt and Equity Securities [Abstract]

INVESTMENTS

Investments consist of the following:



	Accumulated Cost		Unrealized				Market Value
June 30, 2019	Accumulated Cost		Gain		(Loss)		Market Value
Short-term investments
Government securities	$	998	$	—	$	—	$	998
Total	$	998	$	—	$	—	$	998



	Accumulated Cost		Unrealized				Market Value
December 31, 2018	Accumulated Cost		Gain		(Loss)		Market Value
Short-term investments
Government securities	$	2,746	$	—	$	—	$	2,746
Total	$	2,746	$	—	$	—	$	2,746

There were no long-term investments at June 30, 2019, and December 31, 2018.

FAIR VALUE MEASUREMENTS

6 Months Ended

Jun. 30, 2019

Fair Value Disclosures [Abstract]

FAIR VALUE MEASUREMENTS

The Company has certain financial assets recorded at fair value which have been classified as either Level 1 or 2 within the fair value hierarchy as described in the accounting standards for fair value measurements. Fair value is the price that would be received from the sale of an asset or the price paid to transfer a liability in an orderly transaction between independent market participants at the measurement date. Fair values determined by Level 1 inputs utilize observable data such as quoted prices in active markets. Fair values determined by Level 2 inputs utilize data points other than quoted prices in active markets that are observable either directly or indirectly. Fair values determined by Level 3 inputs utilize unobservable data points in which there is little or no market data, which require the reporting entity to develop its own assumptions. The fair value hierarchy level is determined by the lowest level of significant input. At June 30, 2019 and December 31, 2018, the Company did not own any Level 3 financial assets.

The Company’s financial assets classified as Level 2 at June 30, 2019 and December 31, 2018, were initially valued at the transaction price and subsequently valued utilizing third-party pricing services. Because the Company’s investment portfolio may include securities that do not always trade on a daily basis, the pricing services use many observable market inputs to determine value including reportable trades, benchmark yields and benchmarking of like securities. The Company validates the prices provided by the third-party pricing services by reviewing their pricing methods and obtaining market values from other pricing sources. After completing the validation procedures, the Company did not adjust or override any fair value measurements provided by these pricing services as of June 30, 2019 and December 31, 2018.

The tables below present information about the Company’s assets that are measured at fair value on a recurring basis as of June 30, 2019 and December 31, 2018 and indicate the fair value hierarchy of the valuation techniques utilized to determine such fair value.



	Fair value measurements at reporting date using
	Quoted prices in active markets for identical assets		Significant other observable inputs		Significant unobservable inputs		Balance as of
Description	(Level 1)		(Level 2)		(Level 3)		June 30, 2019
Cash equivalents:
Money market funds	$	2,371	$	—	$	—	$	2,371
Short-term investments:
U.S. government and agency securities	—		998		—		998
Total	$	2,371	$	998	$	—	$	3,369



	Fair value measurements at reporting date using
	Quoted prices in active markets for identical assets		Significant other observable inputs		Significant unobservable inputs		Balance as of
Description	(Level 1)		(Level 2)		(Level 3)		December 31, 2018
Cash equivalents:
Money market funds	$	2,663	$	—	$	—	$	2,663
Short-term investments:
U.S. government agency securities	—		2,746		—		2,746
Total	$	2,663	$	2,746	$	—	$	5,409

There were no transfers of financial assets between category levels for the three and six months ended June 30, 2019.

The Company owns 648,149 shares of Series A Redeemable Convertible Preferred Stock of Tepha, Inc. ("Tepha"), a privately held medical device company located in Lexington, Massachusetts, that is engaged in the development of medical device products that restore, maintain, or improve tissue function. The Company received the preferred shares from Tepha during 2002 in connection with a technology sublicense agreement that was later terminated during 2016. The preferred shares owned by the Company represent less than one percent of Tepha's current outstanding common shares on a fully diluted basis and were fully written off through an impairment charge during 2005 prior to Tepha initiating commercial product sales.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

ACCRUED EXPENSES

6 Months Ended

Jun. 30, 2019

Payables and Accruals [Abstract]

ACCRUED EXPENSES

Accrued expenses consisted of the following at:



	June 30, 2019		December 31, 2018
Employee compensation and benefits	$	217	$	98
Leased facilities	36		50
Professional services	169		234
Other	164		298
Total accrued expenses	$	586	$	680

STOCK-BASED COMPENSATION

6 Months Ended

Jun. 30, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

STOCK-BASED COMPENSATION

Expense Information for Employee and Non-Employee Stock Awards

The Company recognized stock-based compensation expense related to stock awards, including awards to non-employees and members of the Board of Directors of $113 and $275 for the three and six months ended June 30, 2019. During the three and six months ended June 30, 2018, the Company recognized $315 and $596 of stock-based compensation expense, respectively. At June 30, 2019, there was approximately $1,461 of pre-tax stock-based compensation expense related to unvested awards not yet recognized.

The compensation expense related to unvested stock options is expected to be recognized over a remaining weighted average period of 3.35 years.

Stock Options

A summary of option activity for the six months ended June 30, 2019 is as follows:



	Number of Shares		Weighted Average Exercise Price
Outstanding at December 31, 2018	1,745,037		$	6.38
Granted	710,275		$	0.91
Exercised	—		—
Forfeited	(7,500	)	$	1.43
Expired	(1,730	)	$	287.80
Outstanding at June 30, 2019	2,446,082		$	4.61

Options vested and expected to vest at June 30, 2019	2,446,082		$	4.61
Options exercisable at June 30, 2019	1,037,393		$	9.12

Restricted Stock Units

The Company records stock compensation expense for restricted stock units ("RSUs") on a straight-line basis over their requisite service period, which approximates the vesting period, based on each RSU's award date market value. As RSUs vest, the Company withholds a number of shares from its employees with an aggregate fair market value equal to the minimum tax withholding amount (unless the employee makes other arrangements for payment of the tax withholding) from the common stock issuable at the vest date. The Company then pays the minimum required income tax for the employees. During the six months ended June 30, 2019 and June 30, 2018, the Company paid $4 and $6, respectively, for income tax withholdings associated with RSUs during these periods.

A summary of RSU activity for the six months ended June 30, 2019 is as follows:



	Number of RSUs		Weighted Average Remaining Contractual Life (years)
Outstanding at December 31, 2018	7,101
Awarded	—
Common stock issued upon vesting	(7,101	)
Forfeited	—
Outstanding at June 30, 2019	—		—

As of June 30, 2019, the Company had no remaining unvested RSUs outstanding.

LEASES

6 Months Ended

Jun. 30, 2019

Leases [Abstract]

LEASES

New Lease Accounting

Topic 842 is effective for annual reporting periods beginning after December 15, 2018 and for interim periods within those fiscal years. The Company adopted Topic 842 on January 1, 2019 and elected to apply the new lease accounting requirements to its financial statements beginning on January 1, 2018 (the earliest period presented in its comparative financial statements), using a modified retrospective approach. The new guidance also requires additional financial statement disclosures to enable users of financial statements to better assess the amount, timing, and uncertainty of cash flows arising from leases. Topic 842 replaced the previous lease accounting and reporting guidance of ASC Topic 840, Leases, ("ASC Topic 840") and requires lessees to reflect a right-of-use asset and a lease liability on their balance sheet for leases with terms of more than twelve months.

The Company's enactment of Topic 842, effective on January 1, 2019, resulted in it recording right-of-use assets and lease liabilities for real estate and equipment leases of $4,766 and $6,465, respectively, as of that date. The Company also eliminated $1,005 in lease incentive obligations from its balance sheet on January 1, 2019 as a result of the discontinuation of the previous guidance under ASC Topic 840. Application of the new pronouncement to the Company's 2018 comparative year had a material effect on its previously issued 2018 financial statements. The Company's condensed consolidated balance sheet as of December 31, 2018 and its condensed consolidated statements of operations, comprehensive income (loss), cash flows and stockholders' equity for the three and six months ended June 30, 2018, included herein, have been adjusted to incorporate the guidance of Topic 842.

Under Topic 842, leases are classified as either operating or finance leases, with classification based on criteria similar to previous lease accounting guidance, but without the explicit quantitative determining factors used to establish a lease as either a capital or an operating lease. The Company reviewed its 2018 transitional leases and its currently active leases falling within the scope of Topic 842 and determined that all of these leases met the criteria for classification as operating leases.

Lease liabilities are recorded as of their commencement date and are calculated as the present value of the remaining lease payments, using the interest rate implicit in the lease, or if that rate is not readily determinable, using the lessee's incremental borrowing rate. Right-of-use assets are equal to the lease liability with adjustments made, as necessary, for lease prepayments, lease accruals, initial direct costs, lessor lease incentives and any lease impairments that may be present. Topic 842 further requires that lease expense for operating leases be calculated on a straight-line basis and reported as a single operating expense within income from operations.

Topic 842 provides a number of transitional practical expedients designed to assist lessees with initial implementation. The Company made the following elections in applying Topic 842.


•	Short-term lease exception. Active leases as of January 1, 2018, and new leases entered into thereafter with terms of twelve months or less were and will be excluded from accounting under Topic 842.

•

Package of practical expedients. These expedients, which must be elected in their entirety, permit a company to continue its historical accounting during the transition period for contractual arrangements containing embedded leases in lieu of performing a re-evaluation of the agreements in order to separate lease and non-lease components. The package of expedients also permit a company to maintain its previous accounting classification for transitional leases as either operating or finance leases without reassessment under the new guidance. Lastly, the package of practical expedients does not require reassessment and capitalization of initial direct costs incurred to establish a lease.

In applying the guidance of Topic 842 to the 2018 transition period, the Company did not elect the available hindsight expedient with respect to the determination of lease terms used in the calculation of lease liabilities and right-of-use assets by considering the actual outcome of lease renewals.

Maturity Analysis of Lease Liabilities

At June 30, 2019, the Company's lease liabilities will mature as follows:



Year ended December 31,	Undiscounted Cash Flows
2019 (July to December)	$	637
2020	1,080
2021	939
2022	969
2023	998
Thereafter	3,082
Total undiscounted future lease payments	7,705
Discount	(1,644		)
Total lease liabilities	$	6,061
Short-term lease liabilities	$	865
Long-term lease liabilities	$	5,196

At June 30, 2019, real estate and equipment leases represent approximately 99% and 1%, of the Company's lease liabilities, respectively.

Quantitative Disclosure of Lease Costs (unaudited)



	Three Months Ended June 30,						Six Months Ended June 30,
	2019			2018			2019			2018
Lease cost:
Operating lease cost	$	257		$	272		$	516		$	538
Short-term lease cost	108			139			254			257
Sublease income	(134		)	(113		)	(258		)	(232		)
Total lease cost, net	$	231		$	298		$	512		$	563

Other information as of:							June 30, 2019			December 31, 2018
Weighted-average remaining lease term (years)							7.1			7.4
Weighted-average discount rate							6.75%			6.75%

Impact of Topic 842 Adoption on Reported Results

Adoption of the new lease standard impacted the Company's 2018 previously reported financial statements as follows (unaudited):



	Three Months Ended June 30, 2018
	As Reported			New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Statements of Income:
Revenue	$	285		$	—		$	285
Expenses	2,705			11			2,716
Other Income (expense)	30			8			38
Net loss	(2,390		)	(3		)	(2,393		)
Basic and diluted net loss per share	(0.24		)	—			(0.24		)



	Six Months Ended June 30, 2018
	As Reported			New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Statements of Income:
Revenue	$	345		$	—		$	345
Expenses	5,072			21			5,093
Other Income (expense)	47			16			63
Net loss	(4,680		)	(5		)	(4,685		)
Basic and diluted net loss per share	(0.48		)	—			(0.48		)



	June 30, 2018
	As Reported		New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Balance Sheet:
Current assets	$	10,104	$	—		$	10,104
Restricted cash	332		—			332
Property and equipment, net	1,477		—			1,477
Right-of-use assets	—		5,209			5,209
Other assets	98		—			98
Total assets	$	12,011	$	5,209		$	17,220

Liabilities and Stockholders' Equity:
Accounts payable	$	34	$	—		$	34
Accrued expenses	1,455		(584		)	871
Short-term lease liabilities	—		739			739
Lease incentive obligation, net of current portion	941		(941		)	—
Long-term lease liabilities	—		6,000			6,000
Stockholders' equity	9,581		(5		)	9,576
Total liabilities and stockholders' equity	$	12,011	$	5,209		$	17,220



	December 31, 2018
	As Reported		New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Balance Sheet:
Current assets	$	6,377	$	—		$	6,377
Restricted cash	332		—			332
Property and equipment, net	1,385		—			1,385
Right-of-use assets	—		4,766			4,766
Other assets	100		—			100
Total assets	$	8,194	$	4,766		$	12,960

Liabilities and Stockholders' Equity:
Accounts payable	$	117	$	—		$	117
Accrued expenses	1,429		(749		)	680
Short-term lease liabilities	—		844			844
Lease incentive obligation, net of current portion	935		(935		)	—
Long-term lease liabilities	—		5,621			5,621
Stockholders' equity	5,713		(15		)	5,698
Total liabilities and stockholders' equity	$	8,194	$	4,766		$	12,960

Real Estate Leases

During 2016, the Company entered into a lease agreement for its headquarters, pursuant to which the Company leases approximately 29,622 square feet of office and research and development space located at 19 Presidential Way, Woburn, Massachusetts. The lease began on June 1, 2016 and will end on November 30, 2026. The lease agreement does not include any options for the early termination or the extension of the lease. The Company provided the landlord with a security deposit in the form of a letter of credit in the amount of $307. Pursuant to the lease, the Company will also pay certain taxes and operating costs associated with the premises throughout the term of the lease. During the buildout of the rented space, the landlord paid $889 for tenant improvements to the facility and an additional $444 for tenant improvements that result in increased rental payments by the Company. Upon the adoption of Topic 842, these improvements were recorded as a reduction in the valulation of the right-of-use asset.

In October 2016, the Company entered into a sublease agreement with a subsidiary of CJ CheilJedang Corporation ("CJ") with respect to CJ's sublease of approximately 9,874 square feet of its leased facility located in Woburn, Massachusetts. The sublease space was determined to be in excess of the Company's needs. The sublease is coterminous with the Company's master lease, and CJ will pay rent and operating expenses equal to approximately one-third of the amounts payable to the landlord by the Company, as adjusted from time to time in accordance with the terms of the master lease. Future CJ sublease payments have not been presented as an offset to total undiscounted future lease payments of $7,705 shown in the lease maturity analysis table above. CJ provided the Company with a security deposit of $103 in the form of an irrevocable letter of credit.

The Company also leases approximately 13,702 square feet of office and laboratory space at 650 Suffolk Street, Lowell, Massachusetts. The lease for this facility, as amended, expires in May 2020. The terms of the agreement provide the Company with a five-year option to extend the lease provided written notice is given prior to August 31, 2019. The Company does not intend to elect this option. During July 2018, the Company discontinued further use of the Lowell space, and as a result, the Company recorded a non-cash lease exit charge of $255 for the facility in accordance with ASC Topic 420-10, Exit or Disposal Obligations. The exit charge was recorded as an increase in the Company's lease expense and a reduction to the associated right-of-use asset. The Company will continue to make monthly rental payments for the Lowell facility through its expiration in May 2020.

The Company's wholly-owned subsidiary, Metabolix Oilseeds, Inc. ("MOI"), located in Saskatoon, Saskatchewan, Canada, leases approximately 6,200 square feet of office, laboratory and greenhouse space located within Innovation Place at 410 Downey Road and within the research facility of National Research Council Canada located at 110 Gymnasium Place. None of the leases contain renewal or early termination options. MOI's leases for these facilities expire on various dates through May 2020.

COMMITMENTS AND CONTINGENCIES	6 Months Ended
COMMITMENTS AND CONTINGENCIES	Jun. 30, 2019
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES	COMMITMENTS AND CONTINGENCIES Litigation From time to time, the Company may be subject to legal proceedings and claims in the ordinary course of business. The Company is not currently aware of any such proceedings or claims that it believes will have, individually or in the aggregate, a material adverse effect on its business, financial condition or results of operations. Guarantees As of June 30, 2019 and December 31, 2018, the Company did not have significant liabilities recorded for guarantees. The Company enters into indemnification provisions under various agreements with other companies in the ordinary course of business, typically with business partners and contractors. Under these provisions, the Company generally indemnifies and holds harmless the indemnified party for losses suffered or incurred by the indemnified party as a result of its activities. These indemnification provisions generally survive termination of the underlying agreement. The maximum potential amount of future payments the Company could be required to make under these indemnification provisions is unlimited. However, to date Yield10 Bioscience has not incurred material costs to defend lawsuits or settle claims related to these indemnification provisions. As a result, the estimated fair value of the indemnifications under these agreements is believed to be minimal. Accordingly, the Company has no liabilities recorded for these agreements as of June 30, 2019 and December 31, 2018.

GEOGRAPHIC INFORMATION

6 Months Ended

Jun. 30, 2019

Segment Reporting [Abstract]

GEOGRAPHIC INFORMATION

The geographic distribution of the Company’s grant revenues and long-lived assets are summarized in the tables below:



	U.S.		Canada		Eliminations			Total
Three Months Ended June 30, 2019:
Grant revenue from external customers	$	318	$	—	$	—		$	318
Inter-geographic revenues	—		499		(499		)	—
Revenues	$	318	$	499	$	(499	)	$	318

Three Months Ended June 30, 2018:
Grant revenue from external customers	$	285	$	—	$	—		$	285
Inter-geographic revenues	—		372		(372		)	—
Revenues	$	285	$	372	$	(372	)	$	285

Six Months Ended June 30, 2019:
Net revenues from external customers	$	442	$	—	$	—		$	442
Inter-geographic revenues	—		836		(836		)	—
Net revenues	$	442	$	836	$	(836	)	$	442

Six Months Ended June 30, 2018:
Net revenues from external customers	$	345	$	—	$	—		$	345
Inter-geographic revenues	—		640		(640		)	—
Net revenues	$	345	$	640	$	(640	)	$	345

Foreign revenue is based on the country in which the Company’s subsidiary that earned the revenue is domiciled. During the three and six months ended June 30, 2019, the Company's grant revenue from the Michigan State University ("MSU") sub-award of $318 and $442 represented 100% of total revenue for both periods. During the three and six months ended June 30, 2018, revenue earned from the MSU sub-award totaled $236 for both periods and represented 83% and 68% of total revenue, respectively.

The geographic distribution of the Company’s long-lived assets is summarized as follows:



	U.S.		Canada		Eliminations		Total
June 30, 2019	$	1,276	$	22	$	—	$	1,298
December 31, 2018	$	1,372	$	13	$	—	$	1,385

CAPITAL STOCK

6 Months Ended

Jun. 30, 2019

Stockholders' Equity Note [Abstract]

CAPITAL STOCK

Common Stock

On March 18, 2019, the Company completed a registered direct offering of its common stock. Proceeds from the transaction were approximately $2,932, before issuance costs of $349. Investors participating in the transaction purchased a total of 2,421,662 shares of common stock at a price of $1.2101 per share.

Preferred Stock

The Company's Certificate of Incorporation authorizes it to issue up to 5,000,000 shares of $0.01 par value preferred stock.

In December 2017, the Company closed on a public offering of its securities that included issuance of 3,987 shares of Series A Convertible Preferred Stock. Each preferred share was convertible, at the holder's option, into 445 shares of common stock at a conversion price of $2.25 per share. As of March 19, 2018, all of the 3,987 preferred shares had been converted to an aggregate of 1,772,000 shares of common stock. When converted, the shares of converted Series A Convertible Preferred Stock were restored to the status of authorized but unissued shares of preferred stock, subject to reissuance by the Board of Directors.

Warrants

The following table summarizes information with regard to outstanding warrants to purchase common stock as of June 30, 2019:



Issuance	Number of Shares Issuable Upon Exercise of Outstanding Warrants	Exercise Price		Expiration Date
July 2017 Registered Direct Offering	570,784	$	5.04	January 7, 2024
December 2017 Public Offering - Series A	6,439,000	$	2.25	December 21, 2022
Consultant	30,000	$	2.90	September 11, 2024
Total	7,039,784

On June 15, 2019, 393,300 warrants issued in connection with the Company's private placement of securities on June 15, 2015, expired in accordance with the terms of the securities purchase agreement.

Reserved Shares

The following shares of common stock were reserved for future issuance upon exercise of stock options, vesting of RSUs and conversion of warrants:



	June 30, 2019	December 31, 2018
Stock Options	2,446,082	1,745,037
RSUs	—	7,101
Warrants	7,039,784	7,433,084
Total number of common shares reserved for future issuance	9,485,866	9,185,222

ACCOUNTING POLICIES (Policies)	6 Months Ended
ACCOUNTING POLICIES (Policies)	Jun. 30, 2019
Accounting Policies [Abstract]
Principles of Consolidation	Principles of Consolidation The Company's unaudited condensed consolidated financial statements are prepared in accordance with accounting principles generally accepted in the United States of America. The unaudited condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany transactions were eliminated, including transactions with its Canadian subsidiary, Metabolix Oilseeds, Inc.
Cash, Cash Equivalents and Restricted Cash	Cash, Cash Equivalents and Restricted Cash The Company considers all highly liquid investments purchased with an original maturity date of ninety days or less at the date of purchase to be cash equivalents.
Investments	Investments The Company considers all investments purchased with an original maturity date of more than ninety days at the date of purchase and a maturity date of one year or less at the balance sheet date to be short-term investments. All other investments are classified as long-term. The Company held no long-term investments at June 30, 2019 and December 31, 2018. Other-than-temporary impairments of equity investments are recognized in the Company's statements of operations if the Company has experienced a credit loss and has the intent to sell the investment or if it is more likely than not that the Company will be required to sell the investment before recovery of the amortized cost basis. Realized gains and losses, dividends, interest income and declines in value judged to be other-than-temporary credit losses are included in other income (expense). Any premium or discount arising at purchase is amortized and/or accreted to interest income.
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of grant revenue and expenses during the reporting periods. Actual results could differ from those estimates.
Foreign Currency Translation	Foreign Currency Translation Foreign denominated assets and liabilities of the Company's wholly owned foreign subsidiaries are translated into U.S. dollars at the prevailing exchange rates in effect on the balance sheet date. Revenues and expenses are translated at average exchange rates prevailing during the period. Any resulting translation gains or losses are recorded in accumulated other comprehensive income (loss) in the consolidated balance sheet. When the Company dissolves, sells or substantially sells all of the assets of a consolidated foreign subsidiary, the cumulative translation gain or loss of that subsidiary is released from comprehensive income (loss) and included within its consolidated statement of operations during the fiscal period when the dissolution or sale occurs.
Income Taxes	Income Taxes The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the consolidated financial statements or in the Company's tax returns. Under this method, deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. A valuation allowance is provided to reduce the deferred tax asset to a level which, more likely than not, will be realized.
Concentration of Credit Risk	Concentration of Credit Risk Financial instruments that potentially subject the Company to concentrations of credit risk primarily consist of cash, cash equivalents and investments. The Company has historically invested its cash equivalents in highly rated money market funds, corporate debt, federal agency notes and U.S. treasury notes. Investments, when purchased, are acquired in accordance with the Company’s investment policy which establishes a concentration limit per issuer.

- Definition

Disclosure of accounting policy for income taxes, which may include its accounting policies for recognizing and measuring deferred tax assets and liabilities and related valuation allowances, recognizing investment tax credits, operating loss carryforwards, tax credit carryforwards, and other carryforwards, methodologies for determining its effective income tax rate and the characterization of interest and penalties in the financial statements.

+ References + Details

- Definition

Disclosure of accounting policy for investments in financial assets, including marketable securities (debt and equity securities with readily determinable fair values), investments accounted for under the equity method and cost method, securities borrowed and loaned, and repurchase and resale agreements. For marketable securities, the disclosure may include the entity's accounting treatment for transfers between investment categories and how the fair values for such securities are determined. Also, for all investments, an entity may describe its policy for assessing, recognizing and measuring impairment of the investment.

+ References + Details

ACCOUNTING POLICIES (Tables)

6 Months Ended

Jun. 30, 2019

Accounting Policies [Abstract]

Schedule of Restricted Cash and Cash Equivalents

The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the Company's Unaudited Condensed Consolidated Balance Sheets included herein:



	June 30, 2019		December 31, 2018
Cash and cash equivalents	$	3,252	$	3,023
Restricted cash	332		332
Total cash, cash equivalents and restricted cash	$	3,584	$	3,355

Schedule of Cash and Cash Equivalents

The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the Company's Unaudited Condensed Consolidated Balance Sheets included herein:



	June 30, 2019		December 31, 2018
Cash and cash equivalents	$	3,252	$	3,023
Restricted cash	332		332
Total cash, cash equivalents and restricted cash	$	3,584	$	3,355

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE (Tables)

6 Months Ended

Jun. 30, 2019

Earnings Per Share [Abstract]

Schedule of number of shares of potentially dilutive common stock related to options and warrants that were excluded from the calculation of dilutive shares



	Three Months Ended June 30,		Six Months Ended June 30,
	2019	2018	2019	2018
Options	2,027,870	1,117,827	1,874,968	910,427
Restricted stock units	—	7,101	3,531	10,660
Warrants	7,368,254	10,597,486	7,400,490	10,597,486
Total	9,396,124	11,722,414	9,278,989	11,518,573

INVESTMENTS (Tables)

6 Months Ended

Jun. 30, 2019

Investments, Debt and Equity Securities [Abstract]

Schedule of investment holdings

Investments consist of the following:



	Accumulated Cost		Unrealized				Market Value
June 30, 2019	Accumulated Cost		Gain		(Loss)		Market Value
Short-term investments
Government securities	$	998	$	—	$	—	$	998
Total	$	998	$	—	$	—	$	998



	Accumulated Cost		Unrealized				Market Value
December 31, 2018	Accumulated Cost		Gain		(Loss)		Market Value
Short-term investments
Government securities	$	2,746	$	—	$	—	$	2,746
Total	$	2,746	$	—	$	—	$	2,746

FAIR VALUE MEASUREMENTS (Tables)

6 Months Ended

Jun. 30, 2019

Fair Value Disclosures [Abstract]

Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]



	Fair value measurements at reporting date using
	Quoted prices in active markets for identical assets		Significant other observable inputs		Significant unobservable inputs		Balance as of
Description	(Level 1)		(Level 2)		(Level 3)		June 30, 2019
Cash equivalents:
Money market funds	$	2,371	$	—	$	—	$	2,371
Short-term investments:
U.S. government and agency securities	—		998		—		998
Total	$	2,371	$	998	$	—	$	3,369



	Fair value measurements at reporting date using
	Quoted prices in active markets for identical assets		Significant other observable inputs		Significant unobservable inputs		Balance as of
Description	(Level 1)		(Level 2)		(Level 3)		December 31, 2018
Cash equivalents:
Money market funds	$	2,663	$	—	$	—	$	2,663
Short-term investments:
U.S. government agency securities	—		2,746		—		2,746
Total	$	2,663	$	2,746	$	—	$	5,409

ACCRUED EXPENSES (Tables)

6 Months Ended

Jun. 30, 2019

Payables and Accruals [Abstract]

Schedule of accrued expenses

Accrued expenses consisted of the following at:



	June 30, 2019		December 31, 2018
Employee compensation and benefits	$	217	$	98
Leased facilities	36		50
Professional services	169		234
Other	164		298
Total accrued expenses	$	586	$	680

STOCK-BASED COMPENSATION (Tables)

6 Months Ended

Jun. 30, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of option activity

A summary of option activity for the six months ended June 30, 2019 is as follows:



	Number of Shares		Weighted Average Exercise Price
Outstanding at December 31, 2018	1,745,037		$	6.38
Granted	710,275		$	0.91
Exercised	—		—
Forfeited	(7,500	)	$	1.43
Expired	(1,730	)	$	287.80
Outstanding at June 30, 2019	2,446,082		$	4.61

Options vested and expected to vest at June 30, 2019	2,446,082		$	4.61
Options exercisable at June 30, 2019	1,037,393		$	9.12

Schedule of restricted stock units activity

A summary of RSU activity for the six months ended June 30, 2019 is as follows:



	Number of RSUs		Weighted Average Remaining Contractual Life (years)
Outstanding at December 31, 2018	7,101
Awarded	—
Common stock issued upon vesting	(7,101	)
Forfeited	—
Outstanding at June 30, 2019	—		—

LEASES (Tables)

6 Months Ended

Jun. 30, 2019

Leases [Abstract]

Maturity analysis of lease liabilities

At June 30, 2019, the Company's lease liabilities will mature as follows:



Year ended December 31,	Undiscounted Cash Flows
2019 (July to December)	$	637
2020	1,080
2021	939
2022	969
2023	998
Thereafter	3,082
Total undiscounted future lease payments	7,705
Discount	(1,644		)
Total lease liabilities	$	6,061
Short-term lease liabilities	$	865
Long-term lease liabilities	$	5,196

Quantitative disclosure of lease costs



	Three Months Ended June 30,						Six Months Ended June 30,
	2019			2018			2019			2018
Lease cost:
Operating lease cost	$	257		$	272		$	516		$	538
Short-term lease cost	108			139			254			257
Sublease income	(134		)	(113		)	(258		)	(232		)
Total lease cost, net	$	231		$	298		$	512		$	563

Other information as of:							June 30, 2019			December 31, 2018
Weighted-average remaining lease term (years)							7.1			7.4
Weighted-average discount rate							6.75%			6.75%

Impact of Topic 842 adoption on reported results

Adoption of the new lease standard impacted the Company's 2018 previously reported financial statements as follows (unaudited):



	Three Months Ended June 30, 2018
	As Reported			New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Statements of Income:
Revenue	$	285		$	—		$	285
Expenses	2,705			11			2,716
Other Income (expense)	30			8			38
Net loss	(2,390		)	(3		)	(2,393		)
Basic and diluted net loss per share	(0.24		)	—			(0.24		)



	Six Months Ended June 30, 2018
	As Reported			New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Statements of Income:
Revenue	$	345		$	—		$	345
Expenses	5,072			21			5,093
Other Income (expense)	47			16			63
Net loss	(4,680		)	(5		)	(4,685		)
Basic and diluted net loss per share	(0.48		)	—			(0.48		)



	June 30, 2018
	As Reported		New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Balance Sheet:
Current assets	$	10,104	$	—		$	10,104
Restricted cash	332		—			332
Property and equipment, net	1,477		—			1,477
Right-of-use assets	—		5,209			5,209
Other assets	98		—			98
Total assets	$	12,011	$	5,209		$	17,220

Liabilities and Stockholders' Equity:
Accounts payable	$	34	$	—		$	34
Accrued expenses	1,455		(584		)	871
Short-term lease liabilities	—		739			739
Lease incentive obligation, net of current portion	941		(941		)	—
Long-term lease liabilities	—		6,000			6,000
Stockholders' equity	9,581		(5		)	9,576
Total liabilities and stockholders' equity	$	12,011	$	5,209		$	17,220



	December 31, 2018
	As Reported		New Lease Standard Adjustment			As Adjusted
Condensed Consolidated Balance Sheet:
Current assets	$	6,377	$	—		$	6,377
Restricted cash	332		—			332
Property and equipment, net	1,385		—			1,385
Right-of-use assets	—		4,766			4,766
Other assets	100		—			100
Total assets	$	8,194	$	4,766		$	12,960

Liabilities and Stockholders' Equity:
Accounts payable	$	117	$	—		$	117
Accrued expenses	1,429		(749		)	680
Short-term lease liabilities	—		844			844
Lease incentive obligation, net of current portion	935		(935		)	—
Long-term lease liabilities	—		5,621			5,621
Stockholders' equity	5,713		(15		)	5,698
Total liabilities and stockholders' equity	$	8,194	$	4,766		$	12,960

GEOGRAPHIC INFORMATION (Tables)

6 Months Ended

Jun. 30, 2019

Segment Reporting [Abstract]

Schedule of the geographic distribution of revenues and long-lived assets from continuing operations

The geographic distribution of the Company’s grant revenues and long-lived assets are summarized in the tables below:



	U.S.		Canada		Eliminations			Total
Three Months Ended June 30, 2019:
Grant revenue from external customers	$	318	$	—	$	—		$	318
Inter-geographic revenues	—		499		(499		)	—
Revenues	$	318	$	499	$	(499	)	$	318

Three Months Ended June 30, 2018:
Grant revenue from external customers	$	285	$	—	$	—		$	285
Inter-geographic revenues	—		372		(372		)	—
Revenues	$	285	$	372	$	(372	)	$	285

Six Months Ended June 30, 2019:
Net revenues from external customers	$	442	$	—	$	—		$	442
Inter-geographic revenues	—		836		(836		)	—
Net revenues	$	442	$	836	$	(836	)	$	442

Six Months Ended June 30, 2018:
Net revenues from external customers	$	345	$	—	$	—		$	345
Inter-geographic revenues	—		640		(640		)	—
Net revenues	$	345	$	640	$	(640	)	$	345

Schedule of the geographic distribution of long-lived assets

The geographic distribution of the Company’s long-lived assets is summarized as follows:



	U.S.		Canada		Eliminations		Total
June 30, 2019	$	1,276	$	22	$	—	$	1,298
December 31, 2018	$	1,372	$	13	$	—	$	1,385

CAPITAL STOCK (Tables)

6 Months Ended

Jun. 30, 2019

Stockholders' Equity Note [Abstract]

Schedule of stockholders' equity note, warrants or rights

The following table summarizes information with regard to outstanding warrants to purchase common stock as of June 30, 2019:



Issuance	Number of Shares Issuable Upon Exercise of Outstanding Warrants	Exercise Price		Expiration Date
July 2017 Registered Direct Offering	570,784	$	5.04	January 7, 2024
December 2017 Public Offering - Series A	6,439,000	$	2.25	December 21, 2022
Consultant	30,000	$	2.90	September 11, 2024
Total	7,039,784

Schedule of Stock by Class

The following shares of common stock were reserved for future issuance upon exercise of stock options, vesting of RSUs and conversion of warrants:



	June 30, 2019	December 31, 2018
Stock Options	2,446,082	1,745,037
RSUs	—	7,101
Warrants	7,039,784	7,433,084
Total number of common shares reserved for future issuance	9,485,866	9,185,222

- Definition

Tabular disclosure of an entity's stock, including par or stated value per share, number and dollar amount of share subscriptions, shares authorized, shares issued, shares outstanding, number and dollar amount of shares held in an employee trust, dividend per share, total dividends, share conversion features, par value plus additional paid in capital, the value of treasury stock and other information necessary to a fair presentation, and EPS information. Stock by class includes common, convertible, and preferred stocks which are not redeemable or redeemable solely at the option of the issuer. Includes preferred stock with redemption features that are solely within the control of the issuer and mandatorily redeemable stock if redemption is required to occur only upon liquidation or termination of the reporting entity. If more than one issue is outstanding, state the title of each issue and the corresponding dollar amount; dollar amount of any shares subscribed but unissued and the deduction of subscriptions receivable there from; number of shares authorized, issued, and outstanding.

+ References

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+ Details

- Definition

Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable.

+ References + Details

NATURE OF BUSINESS AND BASIS OF PRESENTATION (Details) $ in Thousands	Jun. 30, 2019 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Unrestricted cash and cash equivalents and short-term investments	$ 4,250

ACCOUNTING POLICIES (Details) - USD ($) $ in Thousands	6 Months Ended
ACCOUNTING POLICIES (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018	Jun. 30, 2018
Concentration of credit risk
Restricted cash	$ 332	$ 332	$ 332
Government Grants
Concentration of credit risk
Receivables/sales (as a percent)	100.00%
Unbilled receivables	$ 251

ACCOUNTING POLICIES - Schedule of Cash And Restricted Cash (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018	Jun. 30, 2018	Dec. 31, 2017
Accounting Policies [Abstract]
Cash and cash equivalents	$ 3,252	$ 3,023
Restricted cash	332	332	$ 332
Total cash, cash equivalents and restricted cash	$ 3,584	$ 3,355	$ 3,500	$ 14,804

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE (Details) - shares	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Antidilutive securities
Antidilutive common stock excluded from the calculation of dilutive shares	9,396,124	11,722,414	9,278,989	11,518,573
Options
Antidilutive securities
Antidilutive common stock excluded from the calculation of dilutive shares	2,027,870	1,117,827	1,874,968	910,427
Restricted stock units
Antidilutive securities
Antidilutive common stock excluded from the calculation of dilutive shares	0	7,101	3,531	10,660
Warrants
Antidilutive securities
Antidilutive common stock excluded from the calculation of dilutive shares	7,368,254	10,597,486	7,400,490	10,597,486

INVESTMENTS (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Short-term Investments [Abstract]
Accumulated Cost	$ 998	$ 2,746
Unrealized Gain	0	0
Unrealized (Loss)	0	0
Market Value	998	2,746
Long-term Investments	0	0
Government securities
Short-term Investments [Abstract]
Accumulated Cost	998	2,746
Unrealized Gain	0	0
Unrealized (Loss)	0	0
Market Value	$ 998	$ 2,746

FAIR VALUE MEASUREMENTS (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Tepha
Fair value measurements
Investment owned (in shares)	648,149
Investment owned, percentage (less than)	1.00%
Fair Value, measurements, recurring
Fair value measurements
Assets, fair value disclosure	$ 3,369	$ 5,409
Fair Value, measurements, recurring \| Money market funds
Fair value measurements
Assets, fair value disclosure	2,371	2,663
Fair Value, measurements, recurring \| U.S. government and agency securities
Fair value measurements
Assets, fair value disclosure	998	2,746
Fair Value, measurements, recurring \| Quoted prices in active markets for identical assets
Fair value measurements
Assets, fair value disclosure	2,371	2,663
Fair Value, measurements, recurring \| Quoted prices in active markets for identical assets \| Money market funds
Fair value measurements
Assets, fair value disclosure	2,371	2,663
Fair Value, measurements, recurring \| Quoted prices in active markets for identical assets \| U.S. government and agency securities
Fair value measurements
Assets, fair value disclosure	0	0
Fair Value, measurements, recurring \| Significant other observable inputs
Fair value measurements
Assets, fair value disclosure	998	2,746
Fair Value, measurements, recurring \| Significant other observable inputs \| Money market funds
Fair value measurements
Assets, fair value disclosure	0	0
Fair Value, measurements, recurring \| Significant other observable inputs \| U.S. government and agency securities
Fair value measurements
Assets, fair value disclosure	998	2,746
Fair Value, measurements, recurring \| Significant unobservable inputs
Fair value measurements
Assets, fair value disclosure	0	0
Fair Value, measurements, recurring \| Significant unobservable inputs \| Money market funds
Fair value measurements
Assets, fair value disclosure	0	0
Fair Value, measurements, recurring \| Significant unobservable inputs \| U.S. government and agency securities
Fair value measurements
Assets, fair value disclosure	$ 0	$ 0

ACCRUED EXPENSES (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018	Jun. 30, 2018
Payables and Accruals [Abstract]
Employee compensation and benefits	$ 217	$ 98
Leased facilities	36	50
Professional services	169	234
Other	164	298
Total accrued expenses	$ 586	$ 680	$ 871

STOCK-BASED COMPENSATION (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Stock-based compensation
Excess Tax Benefit from Share-based Compensation, Financing Activities			$ (4)	$ (6)
Stock-based compensation	$ 113	$ 315	275	$ 596
Employee stock option
Stock-based compensation
Stock-based compensation expense, net of estimated forfeitures, related to unvested awards not yet recognized	$ 1,461		$ 1,461
Weighted average remaining recognition period (years)			3 years 4 months 7 days
Options
Number of Shares
Outstanding at the beginning of the period (in shares)			1,745,037
Granted (in shares)			710,275
Exercised (in shares)			0
Forfeited (in shares)			(7,500)
Expired (in shares)			(1,730)
Outstanding at the end of the period (in shares)	2,446,082		2,446,082
Options vested and expected to vest at the end of the period (in shares)	2,446,082		2,446,082
Options exercisable at the end of the period (in shares)	1,037,393		1,037,393
Weighted Average Exercise Price
Outstanding at the beginning of the period (in dollars per share)			$ 6.38
Granted (in dollars per share)			0.91
Exercised (in dollars per share)			0.00
Forfeited (in dollars per share)			1.43
Expired (in dollars per share)			287.80
Outstanding at the end of the period (in dollars per share)	$ 4.61		4.61
Options vested and expected to vest at the end of the period (in dollars per share)	4.61		4.61
Options exercisable at the end of the period (in dollars per share)	$ 9.12		$ 9.12

STOCK-BASED COMPENSATION - RESTRICTED STOCK UNIT ACTIVITY TABLE (Details) - Restricted stock units	6 Months Ended
	Jun. 30, 2019 shares
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Outstanding (in shares)	7,101
Awarded (in shares)	0
Common stock issued upon vesting (in shares)	(7,101)
Forfeited (in shares)	0
Outstanding (in shares)	0

LEASES - Narrative (Details) $ in Thousands		1 Months Ended		12 Months Ended
LEASES - Narrative (Details) $ in Thousands	Jan. 01, 2019 USD ($)	Jul. 31, 2018 USD ($)	Oct. 31, 2016 USD ($) ft²	Dec. 31, 2016 USD ($) ft²	Jun. 30, 2019 USD ($) ft²	Dec. 31, 2018 USD ($)	Jun. 30, 2018 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Right-of-use assets					$ 4,467	$ 4,766	$ 5,209
Lease liabilities					6,061
Area of real estate property \| ft²				29,622
Security deposit				$ 307
Operating leases, landlord reimbursement for lease improvements				889
Operating leases, landlord reimbursement for lease improvements, additional payments				$ 444
Undiscounted future lease payments					$ 7,705
CJ CheilJedang Corporation
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Area of real estate property \| ft²			9,874
Security deposit			$ 103
Percentage of amounts payable reimbursable by counterparty			33.33%
650 Suffolk Street
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Area of real estate property \| ft²					13,702
Operating leases, renewal term					5 years
Non-cash lease exit charge		$ 255
Subsidiaries
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Area of real estate property \| ft²					6,200
Topic 842
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Right-of-use assets	$ 4,766
Lease liabilities	6,465
Elimination of lease incentive obligations	$ 1,005
Real estate leases
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Percent of lease liabilities					99.00%
Equipment leases
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Percent of lease liabilities					1.00%

LEASES - Maturity Analysis of Lease Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018	Jun. 30, 2018
Leases [Abstract]
2019 (July to December)	$ 637
2020	1,080
2021	939
2022	969
2023	998
Thereafter	3,082
Total undiscounted future lease payments	7,705
Discount	(1,644)
Total lease liabilities	6,061
Short-term lease liabilities	865	$ 844	$ 739
Long-term lease liabilities	$ 5,196	$ 5,621	$ 6,000

LEASES - Quantitative Disclosure of Lease Costs (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Lease cost:
Operating lease cost	$ 257	$ 272	$ 516	$ 538
Short-term lease cost	108	139	254	257
Sublease income	(134)	(113)	(258)	(232)
Total lease cost, net	$ 231	$ 298	$ 512	$ 563
Other information as of:
Weighted-average remaining lease term	7 years 1 month 6 days		7 years 1 month 6 days		7 years 4 months 24 days
Weighted-average discount rate	6.75%		6.75%		6.75%

LEASES - Impact of Topic 842 Adoption on Reported Results (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Mar. 31, 2019	Jan. 01, 2019	Dec. 31, 2018	Mar. 31, 2018	Dec. 31, 2017
Condensed Consolidated Statements of Income:
Revenue	$ 318	$ 285	$ 442	$ 345
Expenses	2,216	2,716	4,625	5,093
Other Income (expense)	27	38	52	63
Net loss	$ (1,871)	$ (2,393)	$ (4,131)	$ (4,685)
Basic and diluted net loss per share (in USD per share)	$ (0.15)	$ (0.24)	$ (0.36)	$ (0.48)
Condensed Consolidated Balance Sheet:
Current assets	$ 5,017	$ 10,104	$ 5,017	$ 10,104			$ 6,377
Restricted cash	332	332	332	332			332
Property and equipment, net	1,298	1,477	1,298	1,477			1,385
Right-of-use assets	4,467	5,209	4,467	5,209			4,766
Other assets	42	98	42	98			100
Total assets	11,156	17,220	11,156	17,220			12,960
Liabilities and Stockholders' Equity:
Accounts payable	55	34	55	34			117
Accrued expenses	586	871	586	871			680
Lease liabilities	865	739	865	739			844
Lease incentive obligation, net of current portion		0		0			0
Long-term lease liabilities	5,196	6,000	5,196	6,000			5,621
Stockholders’ equity	4,454	9,576	4,454	9,576	$ 6,195		5,698	$ 11,633	$ 13,502
Total liabilities and stockholders’ equity	$ 11,156	17,220	$ 11,156	17,220			12,960
As Reported
Condensed Consolidated Statements of Income:
Revenue		285		345
Expenses		2,705		5,072
Other Income (expense)		30		47
Net loss		$ (2,390)		$ (4,680)
Basic and diluted net loss per share (in USD per share)		$ (0.24)		$ (0.48)
Condensed Consolidated Balance Sheet:
Current assets		$ 10,104		$ 10,104			6,377
Restricted cash		332		332			332
Property and equipment, net		1,477		1,477			1,385
Right-of-use assets		0		0			0
Other assets		98		98			100
Total assets		12,011		12,011			8,194
Liabilities and Stockholders' Equity:
Accounts payable		34		34			117
Accrued expenses		1,455		1,455			1,429
Lease liabilities		0		0			0
Lease incentive obligation, net of current portion		941		941			935
Long-term lease liabilities		0		0			0
Stockholders’ equity		9,581		9,581			5,713
Total liabilities and stockholders’ equity		12,011		12,011			8,194
Topic 842
Condensed Consolidated Balance Sheet:
Right-of-use assets						$ 4,766
Topic 842 \| New Lease Standard Adjustment
Condensed Consolidated Statements of Income:
Revenue		0		0
Expenses		11		21
Other Income (expense)		8		16
Net loss		$ (3)		$ (5)
Basic and diluted net loss per share (in USD per share)		$ 0.00		$ 0.00
Condensed Consolidated Balance Sheet:
Current assets		$ 0		$ 0			0
Restricted cash		0		0			0
Property and equipment, net		0		0			0
Right-of-use assets		5,209		5,209			4,766
Other assets		0		0			0
Total assets		5,209		5,209			4,766
Liabilities and Stockholders' Equity:
Accounts payable		0		0			0
Accrued expenses		(584)		(584)			(749)
Lease liabilities		739		739			844
Lease incentive obligation, net of current portion		(941)		(941)			(935)
Long-term lease liabilities		6,000		6,000			5,621
Stockholders’ equity		(5)		(5)			(15)
Total liabilities and stockholders’ equity		$ 5,209		$ 5,209			$ 4,766

GEOGRAPHIC INFORMATION - Distribution of Revenues and Long-Lived Assets (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Geographic Information
Revenue	$ 318	$ 285	$ 442	$ 345
U.S.
Geographic Information
Revenue	318	285	442	345
Canada
Geographic Information
Revenue	499	372	836	640
Operating segments
Geographic Information
Revenue	318	285	442	345
Operating segments \| U.S.
Geographic Information
Revenue	318	285	442	345
Operating segments \| Canada
Geographic Information
Revenue	0	0	0	0
Eliminations
Geographic Information
Revenue	(499)	(372)	(836)	(640)
Eliminations \| Canada
Geographic Information
Revenue	$ 499	$ 372	$ 836	$ 640

GEOGRAPHIC INFORMATION - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Concentration risk
Revenue	$ 318	$ 285	$ 442	$ 345
Grant
Concentration risk
Revenue	318	285	442	345
Grant \| Michigan State University \| Sales
Concentration risk
Revenue	$ 318	$ 236	$ 442	$ 236
Concentration risk (as a percent)	100.00%	83.00%	100.00%	68.00%

GEOGRAPHIC INFORMATION - Schedule of Geographic Distribution (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018	Jun. 30, 2018
Geographic Information
Long-lived assets	$ 1,298	$ 1,385	$ 1,477
Reportable Geographical Components \| U.S.
Geographic Information
Long-lived assets	1,276	1,372
Reportable Geographical Components \| Canada
Geographic Information
Long-lived assets	22	13
Eliminations
Geographic Information
Long-lived assets	$ 0	$ 0

CAPITAL STOCK - Common Stock (Details) - Registered direct offering $ / shares in Units, $ in Thousands	Mar. 18, 2019 USD ($) $ / shares shares
Proceeds from stock offering	$ 2,932
Payments of stock issuance costs	$ 349
Common stock sold (in shares) \| shares	2,421,662
Common stock sold, price (in dollars per share) \| $ / shares	$ 1.2101

CAPITAL STOCK - Preferred Stock (Details) - $ / shares		1 Months Ended
CAPITAL STOCK - Preferred Stock (Details) - $ / shares	Mar. 19, 2018	Dec. 31, 2017	Jun. 30, 2019	Dec. 31, 2018
Class of Stock [Line Items]
Preferred stock, authorized (in shares)			5,000,000	5,000,000
Preferred stock, par value per share (in dollars per share)			$ 0.01	$ 0.01
Number of shares issuable upon conversion (in shares)			7,039,784
Stock issued upon conversion of securities (in shares)	1,772,000
Class B Units
Class of Stock [Line Items]
Shares issued during period (in shares)		3,987
Series A Warrant
Class of Stock [Line Items]
Number of shares issuable upon conversion (in shares)		445
Series A Warrant \| Class B Units
Class of Stock [Line Items]
Investment warrants, exercise price (in shares)		$ 2.25

CAPITAL STOCK - Warrants (Details) - $ / shares	Jun. 15, 2019	Jun. 30, 2019
Class of Warrant or Right [Line Items]
Number of Shares Issuable Upon Exercise of Outstanding Warrants		7,039,784
Warrants expired (in shares)	393,300
July 2017 Registered Direct Offering
Class of Warrant or Right [Line Items]
Number of Shares Issuable Upon Exercise of Outstanding Warrants		570,784
Exercise price of warrants (in dollars per share)		$ 5.04
December 2017 Public Offering - Series A
Class of Warrant or Right [Line Items]
Number of Shares Issuable Upon Exercise of Outstanding Warrants		6,439,000
Exercise price of warrants (in dollars per share)		$ 2.25
Consultant
Class of Warrant or Right [Line Items]
Number of Shares Issuable Upon Exercise of Outstanding Warrants		30,000
Exercise price of warrants (in dollars per share)		$ 2.90

CAPITAL STOCK - Reserved Shares (Details) - shares	Jun. 30, 2019	Dec. 31, 2018
Class of Stock [Line Items]
Total number of common shares reserved for future issuance	9,485,866	9,185,222
Options
Class of Stock [Line Items]
Total number of common shares reserved for future issuance	2,446,082	1,745,037
Restricted stock units
Class of Stock [Line Items]
Total number of common shares reserved for future issuance	0	7,101
Warrants
Class of Stock [Line Items]
Total number of common shares reserved for future issuance	7,039,784	7,433,084